The images shown in (A,B) are representative of three independent experiments

The images shown in (A,B) are representative of three independent experiments. quantification of nascent RNA molecules excludes that the downmodulation arises in the transcription initiation step, rather pointing towards a post-transcriptional mechanism. Indeed, a significantly higher fraction of unspliced mRNA is detected in ubiquitin overexpressing cells, compared to empty vector transfected cells. Our findings suggest…

In keeping with this, TopBP1 was detected in reciprocal BLM immunoprecipitates from cell extracts (Shape?1B), as a result confirming that both proteins most likely exist inside a organic together in cells

In keeping with this, TopBP1 was detected in reciprocal BLM immunoprecipitates from cell extracts (Shape?1B), as a result confirming that both proteins most likely exist inside a organic together in cells. Open in Senktide another window Figure?1 BLM Interacts with TopBP1 via BRCT5 (A) TopBP1 immunoprecipitates from 293FT cell extracts contain BLM. (B) BLM immunoprecipitates…

Thus, when comparing our studies with those that include a temperature in the simulations, our parameter values are to be compared with the corresponding values divided by the temperature

Thus, when comparing our studies with those that include a temperature in the simulations, our parameter values are to be compared with the corresponding values divided by the temperature. between haptotaxis, matrix degradation and active cell movement. We show that for certain conditions the cells are able to both invade the ECM and follow ECM…