The Hc encompasses the neuronal cell binding -trefoil site [3] and membrane translocation units, as well as the Lc cleaves SNARE proteins, necessary for the discharge of acetylcholine in the neuromuscular junction
The Hc encompasses the neuronal cell binding -trefoil site [3] and membrane translocation units, as well as the Lc cleaves SNARE proteins, necessary for the discharge of acetylcholine in the neuromuscular junction. Hctre-Ad2F nasally given with CT induced serum anti-Hctre IgG ELISA and BoNT/A neutralizing antibody titers higher than those induced by Hctre + CT.…